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William M Valentine Selected Research

Ditiocarb (Sodium Diethyldithiocarbamate)

8/2009N,N-diethyldithiocarbamate promotes oxidative stress prior to myelin structural changes and increases myelin copper content.
5/2008Copper accumulation and lipid oxidation precede inflammation and myelin lesions in N,N-diethyldithiocarbamate peripheral myelinopathy.
9/2004N,N-diethyldithiocarbamate produces copper accumulation, lipid peroxidation, and myelin injury in rat peripheral nerve.
6/2003Parenteral N,N-diethyldithiocarbamate produces segmental demyelination in the rat that is not dependent on cysteine carbamylation.

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William M Valentine Research Topics

Disease

5Demyelinating Diseases (Demyelinating Disease)
08/2009 - 06/2003
3Peripheral Nervous System Diseases (PNS Diseases)
01/2020 - 06/2003
2Parkinson Disease (Parkinson's Disease)
12/2013 - 11/2012
2Neurologic Manifestations (Neurological Manifestations)
06/2011 - 01/2008
1Polyneuropathies (Polyneuropathy)
01/2020
1Neoplasms (Cancer)
12/2018
1Neurodegenerative Diseases (Neurodegenerative Disease)
11/2012
1Inflammation (Inflammations)
05/2008
1Necrosis
12/2002

Drug/Important Bio-Agent (IBA)

4Ditiocarb (Sodium Diethyldithiocarbamate)FDA Link
08/2009 - 06/2003
3CopperIBA
05/2008 - 09/2004
2Proteins (Proteins, Gene)FDA Link
11/2012 - 05/2008
2SeleniumIBA
06/2011 - 01/2008
2Disulfiram (Antabuse)FDA Link
09/2004 - 06/2003
1XenobioticsIBA
01/2020
1SolventsIBA
12/2018
1PesticidesIBA
12/2013
1UbiquitinIBA
11/2012
1AntioxidantsIBA
11/2012
1catechol (pyrocatechol)IBA
11/2012
1LipidsIBA
05/2008
14-hydroxy-2-nonenal (4-hydroxynonenal)IBA
05/2008
1Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA
01/2008
1prolinedithiocarbamate (PDTC)IBA
02/2006
1molinate (Jalan)IBA
02/2004
1ThiocarbamatesIBA
02/2004
1Pharmaceutical PreparationsIBA
06/2003
1Cysteine (L-Cysteine)FDA Link
06/2003
1EnzymesIBA
12/2002

Therapy/Procedure

1Therapeutics
12/2018
1Oral Administration
12/2002